Together they performed various experiments, cultivating clones from Shin's teeth and nerves in order to uncover many secrets of genetics. At some point Shin became intrigued by the Uchiha clan and Itachi Uchiha. As such, he began to imitate the Uchiha, adopting their surname and customary clothing, as well as numerous Sharingan which have been implanted all over his body. His Sharingan-embedded right arm was harvested by Orochimaru and transplanted to Danzō Shimura along with some of Hashirama Senju's cells. Some time after this, Shin left Orochimaru's side and took most of his clones with him. Shin is a pragmatic, scientific individual who adheres strongly to the evolutionary principles of survival of the fittest and natural selection, believing that living organisms are slaves to their genes and exist only to survive by passing on their strongest traits to the next generation. As such, he sees conflict as a necessary component of mankind's evolution and seeks to revive Akatsuki and bring an end to the peace of the world, which he believes will cause the human species to stagnate and ultimately become extinct. Though he refers to his clones as sons, he appears to have no fatherly affection for them, instead viewing them as extensions of his own life who should be sacrificed for the sake of his continued survival. He demonstrates this lack of emotion by using one of his clones as a human shield, then harvesting the clone's vital organs to surgically replace his own, killing the clone in the process. Though typically logical, Shin has a peculiar fascination with Itachi Uchiha and has adopted the Uchiha surname as his own, going so far as to outfit his clones in the clan's customary attire. He has come to loathe Sasuke Uchiha for murdering Itachi and bringing shame to the Uchiha clan. He wishes to avenge Itachi by killing Sasuke, and wants to capture Sasuke's daughter, Sarada Uchiha, to use her in pursuit of his goals.
Shin's abilities are still largely unknown. However, given that he was experimented on by Orochimaru and survived, it stands to reason he is very powerful. To which, he was shown calmly engaging the highly skilled Sasuke Uchiha in battle, able to use multiple misdirections to nearly defeat the Uchiha, showing a very cunning mind as well. He seemingly only failed to defeat Sasuke thanks to a surprise attack from Sakura Haruno, who he later also nearly defeat shortly after recovering before Sasuke saved her as well. Shin possesses multiple fully-matured Sharingan implanted about his body. Because of his highly-adaptive body, Shin is able to maintain his Sharingan unhindered unlike most people not of Uchiha blood. At the same time, as all the Sharingan appear to be activated constantly, it can be assumed he has immense levels of chakra. With these eyes, he has heightened perception and is able to perform various complicated attack patterns. He also owns a mysterious creature with a Sharingan, and is able to share vision with it and others and can use his dōjutsu techniques through it as a medium. With his right eye, Shin is capable of using space–time ninjutsu, which he can create a barrier that instantaneously teleports himself and anything else within it to a location. Depending on the situation, he can manipulate the size and shape of the space affected. Through unknown means, Shin was able to awaken the Mangekyō Sharingan. Its pattern is a large circle around the pupil with three points. The same Mangekyō pattern is also reflected on all his Sharingan. His proficiency with this dōjutsu allows him to use his Mangekyō techniques without activating his Mangekyō form. Also with his right eye, he was shown to be able to telekinetically manipulate any tool he brands with a special mark. With it, Shin has shown very refined control, able to manipulate multiple weapons at once to attack his opponent from various angles and likewise able to perform surgery on himself. He is likewise able to manipulate his multiple targets together in unison for form a myriad of shapes for further versatility in battle. As a medical-nin, Shin displays advanced knowledge of human anatomy and surgery. Favouring scalpels in combat, Shin commonly uses his Mangekyō Sharingan's technique to wield the tools telekinetically, expertly striking key points on the body to inhibit movement. He can also use the dōjutsu to perform surgery on himself, allowing him to replace his injured vital organs by transplanting healthy organs from his own clones. Shin possesses a unique genetic make-up that will completely accept any new genetic material, be it tissue, organs or entire limbs, without a chance of rejection, allowing him to fully integrate it into his being. This same trait also made much easier for permanent and separate entity clones of him to be created. Shin is also shown to have great endurance. Despite being severely wounded by Sakura's chakra-enforced punches, he was able to survive long enough be treated with open surgery, which he performed himself while casually talking to the captured Sakura.
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